CN
Cryo-EM reveals mechanisms of natural RNA multivalency

On March 13, 2025, Zhaoming Su and Xuedong Zhou from Sichuan University, together with Siqi Sun from Fudan University, jointly published a research article online in Science titled...

Structural basis of circularly permuted group II intron self-splicing

January 31, 2025. Congrats to Liu Wang, Jiahao and Chong Zhang on presenting cryo-EM structures of a natural CP intron in different states during back-splicing at a resolution of 2...

RNA sample optimization for cryo-EM analysis

January 31, 2025. Congrats to Liuwang, Jiahao and Chongzhang on presenting an iterative approach of RNA sample optimization for cryo-EM analysis, combined with data processing to r...

The WDR11 complex is a recceptor cargo proteinsfor acidic-cluster-containing

August 8, 2024. Congrats to Guowen on the awesome collaboration with Huaqing, Ping, Yingying and Lin from Da Jia's lab on resolving the cryo-EM structure of WDR11 complex and ...

Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing

March 23, 2023. Congrats to Bingnan and Chong Zhang resolving six conformations associated with Tetrahymena group I intron self-splicing at 2.84-3.73 Å directly following by in vi...

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

February 24, 2023. Congrats to Xinyu Zhiling on the awesome collaboration with Yangyuan from Kelei Zhao's of Chengdu University resolving the cryo-EM structure of sRNA RsmZ co...

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution

The latest research results in the journal Nature—Cryo-EM Structures of Full-Length Tetrahymena Ribozyme at 3.1 Å Resolution published in in the journal Nature.

Welcome to

SuLab!

We are a multidisciplinary lab that integrates cryo-EM, synthetic chemistry and chemical biology to study the structure-function relationship of pathogenic non-coding RNAs and RNPs, and to develop bioactive small molecules that specifically target these RNAs.

We are also interested in developing deep learning algorithms to facilitate cryo-EM image processing and computer-aided drug design.

Research