Publications-Sulab

2025: 55. Jia, X., Zhang, C., Luo, B., Frandsen, J.K., Watkins, A.M., Li, K., Zhang, M., Wei, X., Yang, Y.*, Henkin, T.M.*, Su, Z.*, Insertions in tRNA and T-box RNA modulate ligand recognition and translational regulation. 2025.; 54. Wu, X.#, Luo, Y.#, Feng, S.#, Wang, K.*, Su, Z.*, Yang, D.*, Structural basis for recognition of two different drugs by human OAT1, Sci. Adv., 2025.; 52. Yong, X.#, Jia, G.#, Yang, Q.#, Zhou, C.#, Zhang, S., Deng, H., Billadeau, D.D., Su, Z.*, Jia, D.*, Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Podlak syndrome, Nat. Commun., 2025

2024: 52. Chen, X.#, Wang, L.#, Xie, J.#, Nowak, J.S., Luo, B., Zhang, C., Jia, G., Zou, J., Huang, D., Glatt, S., Yang, Y., Su, Z.*, RNA sample optimization for cryo-EM analysis. Nat. Protoc., 2024, 1-44.; 51. Bu, F., et al., Westhof, E.*, Miao, Z.*, RNA-puzzles round V: Blind predictions of 23 RNA structures. Nat. Methods, 2024, 1-13.; 50. Lu, K.#, Luo, B.#, Tao, X.#, Luo, Y., Li, H., Xie, Y., Zhao, Z., Xia, W.*, Su, Z.*, Mao, Z.*, Complex structure and activation mechanism of arginine kinase McsB by McsA. Nat. Chem. Biol., 2024, 1-10.; 49. Deng, H.#, Jia, G.#, Zhao, L.#, Tang, Y.#, Li, P.#, Yang, Q., Zhao, J., Wang, J., Tu, Y., Yong, X., Zhang, S., Mo, X., Billadeau, D.D., Su, Z.*, Jia, D.*, WDR11 complex is a receptor for acidic cluster-containing cargo proteins. Cell, 2024, 187(16):4272-4288.; 48. Lyu, Y.#, Fu, C.#, Ma, H.#, Su, Z.*, Sun, Z.*, Zhou, X.*, Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding. 2024, Nat. Commun., 2024, 15: 6511.; 47. Ren, W.#, Hong, W.#, Yang, J.#, Zou, J.#, et al., Zhang, K.*, Dai, L.*, Lu, S.*, Wei, X.*, SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease. J. Clin. Invest., 2024, 134(18):e174304.; 46. Tong, Z.#, Tong, J.#, Lei, W.#, et al., Lou, J.*, Gao, G.F.*, Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1 and JN.1. Cell Rep., 2024, 43(6).; 45. Hong, T.#, Luo, Q.#, Ma, H.#, Wang, X.#, Li, X., Shen, C., Pang, J., Wang, Y., Chen, Y., Zhang, C., Wang, X., Su, Z.*, Dong, H.*, Tang, X.*, Cryo-EM reveals the mechanism of TPR-CHAT negative regulation of CRISPR-Cas7-11. Signal Transduct. Target. Ther., 2024, 9(1), 111.; 44. Yang, L.#, Chen, Y.#, Chang, S.#, Wang, X., Zhang, C., Zhang, Z., Ding, B.-S., Su, Z.*, Dong, H.*, Tang, X.*, Structural insights into the activation of the divisome complex FtsWIQLB. Cell Discov., 2024, 10(1): 2.; 43. Zhu, Y.#, Luo, B.#, Mou, X.#, Song, Y.#, Zhou, Y., Luo, Y., Sun, B., Luo, Y., Tang, H.*, Su, Z.*, Bao, R.*, Pseudomonas aeruginosa regulator PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation. Sci. China Life Sci., 2024, 67(5):900-912.

2023

42. Lai, Y.#, Zhao, C.#, Tian, Z.#, Wang, C.#, Fan, J.#, et al., Liu, C.*, Brunger, A.T.*, Diao, J.*, Neutral lysophosphatidylcholine mediates α-synuclein induced synaptic vesicle clustering. Proc. Natl. Acad. Sci.
USA, 2023, 120(44): e2310174120.

41. Kretsch, R.C.*, et al., Moult, J.*, Kryshtafovych, A.*, RNA target highlights in CASP15: Evaluation of predicted models by structure providers. Proteins: Structure, Function, and Bioinformatics, 2023, 91(12), 1600-1615.

40. Wang, Y.#, Zhang, C.#, Luo, Y., Ling, X., Luo, B., Jia, G., Su, D., Dong, H. and Su, Z.*, Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus. Signal Transduct. Target. Ther., 2023, 8(1), 323.

39. Xia, A.#, Yong, X.#, Zhang, C.#, Lin, G.#, Jia, G.#, Zhao, C.#, Wang, X.#, Hao, Y.#, et al., Zhou, R.*, Dong, H.*, Shao, Z.*, Yang, S.*, Cryo-EM structures of human GPR34 enable the discovery of selective antagonists. Proc. Natl. Acad. Sci. USA, 2023, 120(39): e230843512

38. Liu, C., Zhang, H., Peng, X., Blackledge, M.S., Furlani, R.E., Li, H., Su, Z., Melander, R.J., Melander, C., Michalek, S., Wu, H.*, Small molecule attenuates bacterial virulence by targeting conserved response regulator. Mbio, 2023, e00137-23.

37. Tang, D.#, Jia, T.#, Luo, Y.#, Mou, B., Cheng, J., Qi, S., Yao, S., Su, Z.*, Yu, Y.*, Chen, Q.*, DnaQ mediates the directional spacer acquisition in CRISPR-Cas system by a time-dependent mechanism. Innovation, 2023, 4(5):100495.
40.Wang, Y.#, Ling, X.#, et al., Ma, J.*, Liu, C.*, Su, Z.*, Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly. Mol. Biomed., 2023, 4(1):16.

36. Yong, X.#, Jia, G.#, Liu, Z.#, Zhou, C., Yi, J., Tang, Y., Chen, L., Chen, L., Wang, Y., Sun, Q., Billadeau, D.D., Su, Z.*, Jia, D.*, Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc. Natl. Acad. Sci. USA, 2023, 120(22): e2301725120.

35. Luo, B.^#, Zhang, C.^#, Ling, X., Mukherjee, S., Jia, G., Xie, J., Jia, X., Liu, L., Baulin, E. F., Luo, Y., Jiang, L., Dong, H., Wei, X., Bujnicki, J. M. & Su, Z.^* Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing. Nature Catalysis, 2023. doi:10.1038/s41929-023-00934-3

34. Jia, X.^#, Pan, Z.^#, Yuan, Y.^#, Luo, B., Luo, Y., Mukherjee, S., Jia, G., Liu, L., Ling, X., Yang, X., Miao, Z., Wei, X., Bujnicki, J. M., Zhao, K.^* & Su, Z.^* Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Research, 2023. doi:10.1038/s41422-023-00786-3

2022

33. Zhang, G.^#, Guo, C.^#, Wang, Y.^# et al. FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. Journal of Hematol & Oncology, 2022, 15(1), 1-6. doi.org/10.1186/s13045-022-01395-0

32. Zhang S.^#, Fu C.^#, Luo Y.^#, Xie Q., Xu T., Sun Z., Su Z.^*, & Zhou X.^* Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn²⁺-releasing mechanism. Journal of Structural Biology, 2022, 215(1), 107926. doi: 10.1016/j.jsb.2022.107926.

31. Sun, W., Yang, K., Wang, Z., Niu, M., Luo, T., Su, Z., Li, R.^* & Fu, Q.^* Ultrahigh Molecular Weight Polyethylene Lamellar‐Thin Framework on Square Meter Scale. Advanced Materials, 2022, 34(46), 2107941. doi:10.1002/adma.202107941.

30. Ma, H., Pham, P., Luo, B., Rangan, R., Kappel, K., Su, Z.^* & Das, R.^* Auto-DRRAFTER: Automated RNA Modeling Based on Cryo-EM Density. RNA Structure and Dynamics, 2022, 2568, 193-211. doi: 10.1007/978-1-0716-2687-0_13

29. He, C.^#, Yang, J.^#, Hong, W.^# et al. A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant. Nature Communications, 2022, 13(1), 5459. https://doi.org/10.1038/s41467-022-33209-9

28. Li, S., Palo, M. Z., Pintilie, G., Zhang, X., Su, Z., Kappel, K., Chiu, W.^*, Zhang, K.^*& Das, R.^*Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proceedings of the National Academy of Sciences, 2022, 119(37), e2209146119. doi:10.1073/pnas.2209146119.

27. Li, Y.^#, Lu, S.^#, Gu, J.^#et al. SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation. Protein & Cell, 2022, 13(8), 602-614. doi:10.1007/s13238-022-00905-7.

26. Xu, Y.^#, Jia, G.^#, Li, T.^#, Zhou, Z.^#, Luo, Y., Chao, Y., Bao, J., Su, Z.^*, Qu, Q.^*, & Li, D.^* Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins. Nature Communications, 2022,13(1), 2617. doi:10.1038/s41467-022-30250-6

25. Hong, W., et al. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cellular & Molecular Immunology, 2022 . doi:10.1038/s41423-022-00845-6

24. Ma, H., Jia, X., Zhang, K., Su, Z.^* Cryo-EM advances in RNA structure determination. Signal Transduction and Targeted Therapy, 2022, 7(1). https://doi.org/10.1038/s41392-022-00916-0

2021

22. Lyu, J., Yang, M., Zhang, C., Luo, Y., Qin, T., Su, Z., Huang, Z.* DNA nanostructures directed by RNA clamps. Nanoscale, 2021; doi:10.1039/D1NR03919A (2021).

21. Shen L., Su. Z, Yang K., Wu C., Becker T., Pedersen D.B., Zhang J., Sachs M.S.^* Structure of the translating Neurospora ribosome arrested by cycloheximide. PNAS, 2021, 118 (48), e2111862118. doi: 10.1073/pnas.2111862118

20. Yuan Y.^#, Jia G.^#, Wu C.^#, Wang W.^#, Cheng L, Li Q., Li Z., Luo K., Yang S., Yan W.^*, Su Z.^* & Shao Z.^* Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Research, 2021. https://www.nature.com/articles/s41422-021-00566-x

19. Su, Z.^#*, Zhang, K.^#, Kappel, K.^#, Li, S., Palo M.Z., Pintilie G.D., Rangan, R., Luo, B., Wei, Y., Das, R.^* & Chiu, W.^*Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. Nature , 2021. https://doi.org/10.1038/s41586-021-03803-w

18. Torabi, S., Chen, Y., Zhang, K., Wang, J., DeGregorio, S., Vaidya, A., Su, Z., Pabit, S., Chiu, W.^*, Pollack, L.^*, & Steitz, J.^*Structural analyses of an RNA stability element interacting with poly(A). PNAS, 2021, 10.1073/pnas.2026656118.

2020

17. Selzer, L.^#, Su, Z.^#, Pintilie, G.D., Chiu, W.^*, Kirkegaard, K.^* Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer. Plos Biology, 2020, 18(9). https://doi.org/10.1371/journal.pbio.3000827

16. Dahlberg, P.D.^#, Perez, D.^#, Su, Z., Chiu, W., Moerner, W.E.^* Cryogenic correlative single-particle photoluminescence spectroscopy and electron tomography for investigation of nanomaterials. Angewandte Chemie International Edition, 2020, 59, 15642. https://doi.org/10.1002/anie.202002856.

15. Kappel, K.^#, Zhang, K.^#, Su, Z.^#, Watkins, A.M., Kladwang, W., Li, S., Pintilie, G.D., Topkar, V.V., Rangan, R., Zheludev, I.N., Yesselman, J.D., Chiu, W.^*, & Das, R.^* Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures. Nature Methods, 2020, 17, 699-707. https://doi.org/10.1038/s41592-020-0878-9

14. Pintilie, G.D.^#, Zhang, K.^#, Su, Z., Li, S., Schmid, M.F., Chiu, W.^* Measurement of atom resolvability in cryoEM maps with Q-scores. Nature Methods, 2020, 17(3), 328-334. https://doi.org/10.1038/s41592-020-0731-1

2019

13. Zhang, K.^#, Li, S.^#, Kappel, K.^#, Pintilie, G.D., Su, Z., Mou, T.-C., Schimid, M.F., Das, R.^*, & Chiu, W.^* Cryo-EM structure of 40-kDa SAM-IV riboswitch RNA at 3.7 Å resolution. Nature Communications, 2019, 10(1), 1-6. https://doi.org/10.1038/s41467-019-13494-7

12. Li, S.^#, Su, Z.^#, Lehmann, J., Stamatopoulou, V., Giarimoglou, N., Henderson, F.E., Fan, L., Pintilie, G.D., Zhang, K., Chen, M., Ludtke, S.J., Wang, Y.-X., Stathopoulos, C., Chiu, W.^*, & Zhang, J.^* Structural basis of amino acid surveillance by higher order tRNA-mRNA interactions. Nature Structural Molecular Biology, 2019, 26(12), 1094-1105. https://doi.org/10.1038/s41594-019-0326-7

2018

11. Qi, X.^#, Zhang, F.^#, Su, Z.^#, Jiang S., Han, D., Ding, B., Liu, Y., Chiu, W., Yin, P.^*, Hao, Y.^* Programming molecular topologies from single-stranded nucleic acids. Nature Communications, 2018, 9(1), 4579. https://doi.org/10.1038/s41467-018-07039-7

10. Ge, Z., Su, Z., Simmons, C.R., Li, J., Jiang, S., Li, W., Yang, Y., Liu, Y., Chiu, W.^*, Fan, C.^*, & Yan, H.^* Redox engineering of eytochrome c using DNA nanostructure-based charged encapsolation and spatial control. ACS Applied Material Interfaces, 2018, 11(15), 13874–13880. https://doi.org/10.1021/acsami.8b07101

9. Zhang, K.^#, Keane, S.^#, Su, Z., Irobalieva, R.N., Chen, M., Van, V., Sciandra, C.A., Marchant, J., Heng, X., Schmid, M.F., Case, D.^*, Ludtke, S.J.^*, Summers, M.F.^*, & Chiu, W.^* Structure of the 30 kDa HIV-1 RNA dimerization signal by a hybrid cryo-EM, NMR and molecular dynamics approach. Structure, 2018, 26(3), 490-498. https://doi.org/10.1016/j.str.2018.01.001

8. Su, Z.^#, Wu, C.^#, Shi, L., Luthra, P., Pintilie, G.D., Britney, J., Porter, J.R., Ge, P., Chen, M., Liu, G., Frederick, T.E., Binning, J.M., Bowman, G.R., Zhou, Z.H., Basler, C.F., Gross, M.L., Leung, D.W., Chiu, W.^*, Amarasinghe, G.K.^* Electron cryo-microscopy structure of Ebola nucleoprotein reveals a mechanism for nucleocapsid-like assembly. Cell, 2018, 172(5), 966-978. https://doi.org/10.1016/j.cell.2018.02.009

2017 and earlier (Selected): 7. Lan, X., Su, Z., Zhou, Y., Meyer, T., Ke, Y., Wang, Q., Chiu, W., Liu, N. Zou, S., Yan, H., Liu, Y.^* Programmable supra-assembly of a DNA surface adapter for tunable chiral directional self-assembly of gold nanorods. Angewandte Chemie International Edition, 2017, 56(46), 14632-14636.; 6. Leung, D.W.^#, Borek, D.M.^#, Luthra, P., Binning, J.M., Anantpadma, M., Liu, G., Harvey, I.B., Su, Z., Endlich-Frazier, A., Pan, J., Shabman, R.S., Chiu, W., Davey, R., Otwinowski, Z., Basler, C.F. & Amarasinghe, G.K.* An intrinsically disordered peptide from Ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions. Cell Reports, 2015, 11(3), 376. http://creativecommons.org/licenses/by/4.0/; 5. Su, Z.^#, Zhang, Y.^#, Gendron, T.F.^#, Bauer, P.O.^#, Chew, J., Yang, W.Y., Fostvedt, E., Jansen-West, K., Belzil, V.V., Desaro, P., Johnston, A., Overstreet, K., Boeve, B.F., Dickson, D., Floeter M.K., Traynor, B.J., Morelli, C., Ratti, A., Silani, V., Rademakers, R., Brown, R.H., Rothstein, J.D., Boylan, K., Petrucelli, L.^* & Disney, M.D.^* Discovery of a biomarker and Lead small molecules to target r(GGGGCC)-Associated defects in c9FTD/ALS. Neuron, 2014, 83(5), 1043-1050. http://dx.doi.org/10.1016/j.neuron.2014.07.041; 4. Su, Z., Yeagley, A.A., Su, R., Peng, L. and Melander, C.^* Structural studies on 4,5-Disubstituted-2-Aminoimidazole-based biofilm modulators that suppress bacterial resistance to β-Lactams. ChemMedChem, 2012, 7(11), 2030-2039. https://doi.org/10.1002/cmdc.201200350; 3. Su. Z, Peng. L, Melander. C.^* A modular approach to the synthesis of 1, 4, 5-substituted-2-aminoimidazoles. Tetrahedron Letters, 2012,53 (10), 1204-1206. 10.1016/j.tetlet.2011.12.090; 2. Su, Z., Peng, L., Worthington, R. J., and Melander, C.^* Evaluation of 4,5-Disubstituted-2-Aminoimidazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and acinetobacter baumannii. ChemMedChem, 2011, 6(12), 2243-2251. https://doi.org/10.1002/cmdc.201100316; 1. Su, Z., Rogers, S. A., McCall, W. S., Smith, A. C., Ravishankar, S., Mullikin, T., and Melander, C. A.^* A nitroenolate approach to the synthesis of 4,5-Disubstituted-2-Aminoimidazoles. pilot library assembly and acreening for antibiotic and antibiofilm activity. Organic & Biomolecular Chemistry, 2010, 8(12), 2814-2822. 10.1039/c001479

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